Drug: Anturane

Anturane, sulfinpyrazone USP, is auricosuric agent available as 100-mg tablets and 200-mg capsules for oral administration. Its chemical name is 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione. Sulfinpyrazone USP is a white to off-white powder practically insoluble in water and in solvent hexane, soluble in alcohol and in acetone, and sparingly soluble in dilute alkali. Its molecular weight is 404.48. Inactive Ingredients Anturane (sulfinpyrazone) tablets: Colloidal silicon dioxide, gelatin, lactose, magnesium stearate, cornstarch, stearic acid, and talc. Anturane (sulfinpyrazone) capsules: D&C Red No. 33, D&C Yellow No. 10, FD&C Blue No. 1, gelatin, lactose, magnesium stearate, methylparaben, propylparaben, silicon dioxide, sodium lauryl sulfate, cornstarch, stearic acid, talc, and titanium dioxide. Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

The most frequently reported adverse reactions with Anturane (sulfinpyrazone) have been upper gastrointestinal disturbances. In these patients it is advisable to administer the drug with food, milk, or antacids. Despite this precaution, Anturane (sulfinpyrazone) may aggravate or reactivate peptic ulcer. Rash has been reported. In most instances, this reaction did not necessitate discontinuance of therapy. In general, Anturane (sulfinpyrazone) has not been observed to affect electrolyte balance. Blood dyscrasias (anemia, leukopenia, agranulocytosis, thrombocytopenia, and aplastic anemia) have rarely been reported. There has also been a published report associating Anturane (sulfinpyrazone) , administered concomitantly with other drugs including colchicine, with leukemia following long term treatment of patients with gout. However, the circumstances involved in the two cases reported are such that a cause-and-effect relationship to Anturane (sulfinpyrazone) has not been clearly established. Read the Anturane (sulfinpyrazone) Side Effects Center for a complete guide to possible side effectsLearn More »

Source: http://www.rxlist.com

Initial 200-400 mg daily in two divided doses, with meals or milk, gradually increasing when necessary to full maintenance dosage in one week. Maintenance 400mg daily, given in two divided doses, as above. This dosage may be increased to 800 mg daily, if necessary, and may sometimes be reduced to as low as 200 mg daily after the blood urate level has been controlled. Treatment should be continued without interruption even in the presence of acute exacerbations, which can be concomitantly treated with phenylbutazone or colchicine. Patients previously controlled with other uricosuric therapy may be transferred to Anturane (sulfinpyrazone) at full maintenance dosage.

Source: http://www.rxlist.com

No information provided.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Anturane (sulfinpyrazone) is indicated for the treatment of: 1. Chronic gouty arthritis 2. Intermittent gouty arthritis

Source: http://www.rxlist.com

Patients with an active peptic ulcer or symptoms of gastrointestinal inflammation or ulceration should not receive the drug. The drug is contraindicated in patients with a history or the presence of: 1. Hypersensitivity to phenylbutazone or other pyrazoles 2. Blood dyacrasias Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Symptoms Nausea, vomiting, diarrhea, epigastric pain, ataxia, labored respiration, convulsions, coma. Possible symptoms, seen after overdosage with other pyrazolone derivatives: anemia, jaundice, ulceration. Treatment No specific antidote. Induce emesis; gastric lavage; supportive treatment (intravenous glucose infusions, analeptics).

Source: http://www.rxlist.com

Tablets 100 mg round, white, scored (imprinted CIBA 41) Bottles of 100                     NDC 0083-0041-30 Capsules 200 mg green (imprinted Anturane (sulfinpyrazone) 200 CIBA 168) Bottles of 100                     NDC 0083-0168-30 Do not store above 86° F (30° C). Dispense in tight container (USP). Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

As with all pyrazole compounds, patients receiving Anturane (sulfinpyrazone) should be kept under close medical supervision and periodic blood counts are recommended. It may be administered with care to patients with a history of healed peptic ulcer. Recent reports have indicated that Anturane (sulfinpyrazone) potentiates the action of certain sulfonamides, such as sulfadiazine and sulfisoxazole. In addition, other pyrazole compounds (phenylbutazone) have been observed to potentiate the hypoglycemic sulfonylurea agents, as well as insulin. In view of these observations, it is suggested that Anturane (sulfinpyrazone) be used with caution in conjunction with sulfa drugs, the sulfonylurea hypoglycemic agents and insulin. Because Anturane (sulfinpyrazone) is a potent uricosuric agent, it may precipitate urolithiasis and renal colic, especially in the initial stages of therapy. For this reason, an adequate fluid intake and alkalinization of the urine are recommended. In cases with significant renal impairment, periodic assessment of renal function is indicated. Occasional cases of renal failure have been reported; but a cause-and-effect relationship has not always been clearly established. Salicylates antagonize the uricosuric action of Anturane (sulfinpyrazone) and for this reason their concomitant use is contraindicated in gouty arthritis. Anturane (sulfinpyrazone) may accentuate the action of coumarin-type anticoagulants and further depress prothrombin activity when these medications are employed simultaneously. Pediatric Use Safety and effectiveness in pediatric patients have not been established. NOTE: Anturane (sulfinpyrazone) has minimal anti-inflammatory effect and is not intended for the relief of an acute attack of gout. In the initial stages of therapy, because of the marked ability of Anturane (sulfinpyrazone) to mobilize urates, acute attacks of gouty arthritis may be precipitated. Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

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