Drug: Bontril SR

Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (+)-3,4-Dimethyl-2-phenylmorpholine Tartrate. The structural formula is as follows:
C12H17NO•C4H6O6.................................M.W. 341.36 Phendimetrazine tartrate is a white, odorless powder with a bitter taste. It is soluble in water, methanol and ethanol. Bontril® (phendimetrazine tartrate slow release capsules) Slow-Release capsules contain FD&C Yellow No. 6 as a color additive.

Source: http://www.rxlist.com

Cardiovascular: Palpitation, tachycardia, elevation of blood pressure. Central Nervous System: Overstimulation, restlessness, dizziness, insomnia, tremor, headache; rarely psychotic episodes at recommended doses, agitation, flushing, sweating, blurring of vision. Gastrointestinal: Dryness of the mouth, diarrhea, constipation, nausea, stomach pain. Genitourinary: Changes in libido, urinary frequency, dysuria. Drug Abuse And Dependence Controlled Substance: Phendimetrazine is a Schedule lll controlled substance. Dependence: Phendimetrazine tartrate is related chemically and pharmacologically to the amphetamines. Amphetamines and related stimulant drugs have been extensively abused, and the possibility of abuse of phendimetrazine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction. There are reports of patients who have increased the dosage to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes. The most severe manifestation of chronic intoxications is psychosis, often clinically indistinguishable from schizophrenia. Read the Bontril SR (phendimetrazine tartrate slow release capsules) Side Effects Center for a complete guide to possible side effectsLearn More »

Source: http://www.rxlist.com

One Slow-Release Capsule (105 mg) in the morning, taken 30-60 minutes before the morning meal. Phendimetrazine Tartrate is not recommended for use in children under twelve years of age.

Source: http://www.rxlist.com

No information provided. Read the Bontril SR Drug Interactions Center for a complete guide to possible interactions Learn More »

Source: http://www.rxlist.com

Phendimetrazine tartrate is indicated in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. The limited usefulness of agents of this class (see Actions) should be measured against possible risk factors inherent in their use such as those described below.

Source: http://www.rxlist.com

Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate and severe hypertension, hyperthyroidism, known hypersensitivity, or idiosyncrasy to the sympathomimetic amines, glaucoma. Agitated states. Patients with a history of drug abuse. Use in patients taking other CNS stimulants including monoamine oxidase inhibitors. Last reviewed on RxList: 3/26/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Manifestations of acute overdosage may include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension, or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Poisoning may result in convulsions, coma, and death. Management of acute intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard. Acidification of the urine increases phendimetrazine tartrate excretion. Intravenous phentolamine (Regitine) has been suggested for possible acute, severe hypertension, if this complicates overdosage.

Source: http://www.rxlist.com

Bontril Slow Release Capsules (phendimetrazine tartrate 105 mg) is available as opaque green and clear yellow capsules, imprinted with “VALEANT” and “BONTRIL 105”. Phendimetrazine Slow-Release Capsules are available in bottles of 100 (NDC #0187-0498-01) and 1000 (NDC 0187-0498-02). Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Distributed by: Valeant Pharmaceuticals North America. One Enterprise, Aliso Viejo, CA 92656 USA. Manufactured by: Mallinckrodt Inc. Hobart, NY 13788. Last reviewed on RxList: 3/26/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Caution is to be exercised in prescribing phendimetrazine for patients with even mild hypertension. Insulin requirements in diabetes mellitus may be altered in association with the use of phendimetrazine and the concomitant dietary regimen. Phendimetrazine may decrease the hypotensive effect of guanethidine. The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage. Usage in Pregnancy: Safe use in pregnancy has not been established. Until more information is available, phendimetrazine tartrate should not be taken by women who are or may become pregnant unless, in the opinion of the physician, the potential benefits outweigh the possible hazards. Usage in Children: Phendimetrazine tartrate is not recommended for use in children under 12 years of age. Last reviewed on RxList: 3/26/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

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