Drug: Cordran Tape
Cordran® Tape (Flurandrenolide Tape, USP) is a transparent, inconspicuous, plastic surgical tape, impervious to moisture. It contains Cordran® (Flurandrenolide, USP), a potent corticosteroid for topical use. Flurandrenolide occurs as white to off-white, fluffy crystalline powder and is odorless. Flurandrenolide is practically insoluble in water and in ether. One g dissolves in 72 mL of alcohol and in 10 mL of chloroform. The molecular weight of flurandrenolide is 436.52. The chemical name of flurandrenolide is Pregn-4-ene-3,20-dione, 6-fluoro-11,21 dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α, 11β, 16α)-; its empirical formula is C24 H33 FO6. The structural formula is as follows: Each square centimeter contains 4 μg (0.00916 μmol) flurandrenolide uniformly distributed in the adhesive layer. The tape is made of a thin, matte-finish polyethylene film that is slightly elastic and highly flexible. The adhesive is a synthetic copolymer of acrylate ester and acrylic acid that is free from substances of plant origin. The pressure-sensitive adhesive surface is covered with a protective paper liner to permit handling and trimming before application.
Source: http://www.rxlist.com
The following local adverse reactions are reported infrequently with topical corticosteroids but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: Burning
Itching
Irritation
Dryness
Folliculitis
Hypertrichosis
Acneform eruptions
Hypopigmentation
Perioral dermatitis
Allergic contact dermatitis The following may occur more frequently with occlusive dressings: Maceration of the skin
Secondary infection
Skin atrophy
Striae
Miliaria Read the Cordran Tape (flurandrenolide tape) Side Effects Center for a complete guide to possible side effectsLearn More »
Itching
Irritation
Dryness
Folliculitis
Hypertrichosis
Acneform eruptions
Hypopigmentation
Perioral dermatitis
Allergic contact dermatitis The following may occur more frequently with occlusive dressings: Maceration of the skin
Secondary infection
Skin atrophy
Striae
Miliaria Read the Cordran Tape (flurandrenolide tape) Side Effects Center for a complete guide to possible side effectsLearn More »
Source: http://www.rxlist.com
Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of Cordran Tape (flurandrenolide tape) and other occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted. Replacement of the tape every 12 hours produces the lowest incidence of adverse reactions, but it may be left in place for 24 hours if it is well tolerated and adheres satisfactorily. When necessary, the tape may be used at night only and removed during the day. If ends of the tape loosen prematurely, they may be trimmed off and replaced with fresh tape. The directions given below are included on a separate package insert for the patient to follow unless otherwise instructed by the physician. APPLICATION OF CORDRAN TAPE (flurandrenolide tape) IMPORTANT: Skin should be clean and dry before tape is applied. Tape should always be cut, never torn.
Source: http://www.rxlist.com
No information provided. Last reviewed on RxList: 9/25/2008
This monograph has been modified to include the generic and brand name in many instances.
This monograph has been modified to include the generic and brand name in many instances.
Source: http://www.rxlist.com
For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, particularly dry, scaling localized lesions.
Source: http://www.rxlist.com
Topical corticosteroids are contraindicated in patients with a history of hypersensitivity to any of the components of these preparations. Use of Cordran Tape (flurandrenolide tape) is not recommended for lesions exuding serum or in intertriginous areas.Last reviewed on RxList: 9/25/2008
This monograph has been modified to include the generic and brand name in many instances.
This monograph has been modified to include the generic and brand name in many instances.
Source: http://www.rxlist.com
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS).
Source: http://www.rxlist.com
Tape: 4 mcg/sq cm-small roll, 24 in x 3 in (60 cm x 7.5 cm) NDC 55515-014-24
4 mcg/sq cm-large roll, 80 in x 3 in (200 cm x 7.5 cm) NDC 55515-014-80 Directions for the patient are included in each package. Store at 25°C (77°F); excursions permitted to15-30°C (59-86°F). REFERENCES Bard JW: Flurandrenolide tape in the treatment of lichen simplex chronicus. J Ky Med Assoc 1969;67:668. Baxter DL, Stoughton RB: Mitotic index of psoriatic lesions treated with anthralin, glucocorticosteroid and occlusion only. J Invest Dermatol 1970;54:410. Compilation of clinical reports on Cordran Tape (flurandrenolide tape) received by Eli Lilly and Company. Halprin KM, Fukui K, Ohkawara A: Flurandrenolone (Cordran) tape and carbohydrate metabolizing enzymes. Arch Dermatol 1969;100:336. Labow TA, Eisert J, Sanders SL: Flurandrenolide tape in treatment of psoriasis. NY State J Med 1969;69:3138. Ronchese F: Flurandrenolone tape therapy. RI Med J 1969;52:389. Sellers FM: Investigative study of flurandrenolone tape in a series of ambulatory outpatients. J Indiana State Med Assoc 1970;63:34. Weiner MA: Flurandrenolone tape, a new preparation for occlusive therapy, J Invest Dermatol 1966;47:63. Mfd. by 3M Company, St. Paul, MN 55144. Mfd. For: Oclassen DERMATOLOGICS, A Division of Watson Pharma, Inc. Corona, CA 92880. FDA revision date: 7/19/2000 Last reviewed on RxList: 9/25/2008
This monograph has been modified to include the generic and brand name in many instances.
4 mcg/sq cm-large roll, 80 in x 3 in (200 cm x 7.5 cm) NDC 55515-014-80 Directions for the patient are included in each package. Store at 25°C (77°F); excursions permitted to15-30°C (59-86°F). REFERENCES Bard JW: Flurandrenolide tape in the treatment of lichen simplex chronicus. J Ky Med Assoc 1969;67:668. Baxter DL, Stoughton RB: Mitotic index of psoriatic lesions treated with anthralin, glucocorticosteroid and occlusion only. J Invest Dermatol 1970;54:410. Compilation of clinical reports on Cordran Tape (flurandrenolide tape) received by Eli Lilly and Company. Halprin KM, Fukui K, Ohkawara A: Flurandrenolone (Cordran) tape and carbohydrate metabolizing enzymes. Arch Dermatol 1969;100:336. Labow TA, Eisert J, Sanders SL: Flurandrenolide tape in treatment of psoriasis. NY State J Med 1969;69:3138. Ronchese F: Flurandrenolone tape therapy. RI Med J 1969;52:389. Sellers FM: Investigative study of flurandrenolone tape in a series of ambulatory outpatients. J Indiana State Med Assoc 1970;63:34. Weiner MA: Flurandrenolone tape, a new preparation for occlusive therapy, J Invest Dermatol 1966;47:63. Mfd. by 3M Company, St. Paul, MN 55144. Mfd. For: Oclassen DERMATOLOGICS, A Division of Watson Pharma, Inc. Corona, CA 92880. FDA revision date: 7/19/2000 Last reviewed on RxList: 9/25/2008
This monograph has been modified to include the generic and brand name in many instances.
Source: http://www.rxlist.com
General Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients. Conditions that augment systemic absorption include application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using urinary-free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete on discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, so that supplemental systemic corticosteroids are required. Pediatric patients may absorb proportionately larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity (see Pediatric Use under PRECAUTIONS). If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. In the presence of dermatologic infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, Cordran should be discontinued until the infection has been adequately controlled. Information for the Patient Patients using topical corticosteroids should receive the following information and instructions:
This monograph has been modified to include the generic and brand name in many instances.
- This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.
- Patients should be advised not to use this medication for any disorder other than that for which it was prescribed.
- The treated skin area should not be bandaged or otherwise covered or wrapped in order to be occlusive unless the patient is directed to do so by the physician.
- Patients should report any signs of local adverse reactions, especially under occlusive dressing.
- Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a patient being treated in the diaper area, because these garments may constitute occlusive dressings.
This monograph has been modified to include the generic and brand name in many instances.
Source: http://www.rxlist.com
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