Aminosyn® WITH ELECTROLYTES, Sulfite-Free, (a crystalline amino acid solution with electrolytes) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn WITH ELECTROLYTES is oxygen sensitive. Three different formulations are available. Aminosyn Formulations Essential Amino Acids (mg/100 mL)
Aminosyn 3.5% M* 7% WITH ELECTROLYTES 8.5% WITH ELECTROLYTES Isoleucine 252 510 620 Leucine 329 660 810 Lysine (acetate)** 252 510 624 Methionine 140 280 340 Phenylalanine 154 310 380 Threonine 182 370 460 Tryptophan 56 120 150 Valine 280 560 680 *Contains maintenance electrolytes.
**Amount cited is for lysine alone and does not include the acetate salt. Nonessential Amino Acids (mg/100 mL)
Aminosyn 3.5% M* 7% WITH ELECTROLYTES 8.5% WITH ELECTROLYTES Alanine 448 900 1100 Arginine 343 690 850 Histidine 105 210 260 Proline 300 610 750 Serine 147 300 370 Tyrosine 31 44 44 Glycine 448 900 1100 *Contains maintenance electrolytes. Essential Amino Acids
Isoleucine CH3CH2CH(CH3)CH(NH2)COOH Leucine (CH3)2CHCH2CH(NH2)COOH Lysine Acetate H2N(CH2)4CH(NH2)COOH • CH3COOH Methionine CH3S(CH2)2CH(NH2)COOH Phenylalanine
CH2CH(NH2)COOH Threonine CH3CH(OH)CH(NH2)COOH Tryptophan
CH2CH(NH2)COOH Valine (CH3)2CHCH(NH2)COOH Nonessential Amino Acids
Alanine CH3CH(NH2)COOH Arginine H2NC(NH)NH(CH2)3CH(NH2)COOH Glycine H2NCH2COOH Histidine
CH2CH(NH2)COOH Proline COOH Serine HOCH2CH(NH2)COOH Tyrosine CH2CH(NH2)COOH Electrolytes (mEq/Liter)
Aminosyn 3.5% M* 7% WITH ELECTROLYTES 8.5% WITH ELECTROLYTES Sodium (Na+) 40 65 65 Potassium (K+) 13 65 65 Magnesium (Mg++) 3 10 10 Phosphorus (P) 3.5 (mM)a 30 (mM)a 30 (mM)a Chloride (Cl–) 40 96b 98b Acetate (C2H3O2–) 65c 124d 142d a mM = millimoles; one mM of phosphorus = 31 mg.
b Includes chloride from HCl added for processing and pH adjustment.
c Includes acetate from acetic acid used in processing and the acetate salts of potassium, magnesium and lysine.
d Includes acetate from acetic acid used in processing and from lysine acetate. Product Characteristics
Aminosyn 3.5% M* 7% WITH ELECTROLYTES 8.5% WITH ELECTROLYTES Protein Equivalent (approx. grams/liter) 35 70 85 Total Nitrogen (grams/liter) 5.5 11.00 13.4 Specific Gravity 1.01 1.03 1.03 Osmolarity (mOsmol/liter) 421 883 1040 pH 5.2 (4.5—6.0)e 5.2 (4.5 — 6.0)f 5.2 (4.5 — 6.0)f e Contains acetic acid for pH adjustment.
f Contains hydrochloric acid and acetic acid for pH adjustment. Electrolytes (mg/100 mL)
Aminosyn 3.5% M* Sodium Chlorideg 234 Potassium Acetateh 128 86.5% Phosphoric Acidi 40 Magnesium Acetate, anhydrousj 21 *Contains Maintenance Electrolytes Aminosyn 7% WITH ELECTROLYTES 8.5% WITH ELECTROLYTES Sodium Chlorideg 28 28 Magnesium Chloride, hexahydratek 102 102 Sodium Phosphate, dibasicl 425 425 Potassium Chloridem 487 487 g Sodium Chloride, USP is chemically designated NaCl, a white crystalline powder freely soluble in water.
h Potassium Acetate, USP is chemically designated CH3COOK, colorless crystals or white crystalline powder very soluble in water.
i Phosphoric Acid 86.5%, NF is chemically designated H3PO4, a colorless, syrupy liquid miscible with water.
j Magnesium Acetate is chemically designated magnesium acetate, tetrahydrate, Mg(CH3COO)2 • 4H2O, colorless or white crystals very soluble in water.
k Magnesium Chloride, USP is chemically designated magnesium chloride, hexahydrate, MgCl2 • 6H2O, deliquescent crystals very soluble in water.
l Sodium Phosphate, dibasic, USP is chemically designated Na2HPO4, white granules very soluble in water.
m Potassium Chloride, USP is chemically designated KCI, a white granular powder freely soluble in water. The formulas for the individual amino acids present in Aminosyn are as follows: Essential Amino Acids Isoleucine, USP (C6H13NO2) Leucine, USP (C6H13NO2) Lysine Acetate, USP (C6H14N2O2 • CH3COOH) Methionine, USP (C5H11NO2S) Phenylalanine, USP (C9H11NO2) Threonine, USP (C4H9NO3) Tryptophan, USP (C11H12N2O2) Valine, USP (C5H11NO2) Nonessential Amino Acids Alanine, USP (C3H7NO2) Arginine, USP (C6H14N4O2) Histidine, USP (C6H9N3O2) Proline, USP (C5H9NO2) Serine, USP (C3H7NO3) Tyrosine, USP (C9H11NO3) Glycine, USP (C2H5NO2) The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. Last reviewed on RxList: 1/14/2009
This monograph has been modified to include the generic and brand name in many instances.