Drug: Benzonatate

Benzonatate (benzonatate softgels) , a nonnarcotic oral antitussive agent, is 2,5,8,11,14,17,20, 23,26- nonaoxaoctacosan-28-yl-p-(butylamino) benzoate; with an average molecular weight of 603.7. The chemical formula is C30H53NO11, structural formula is:

Source: http://www.rxlist.com

Potential Adverse Reactions to benzonatate (benzonatate softgels) may include: Hypersensitivity reactions including bronchospasm, laryngospasm, cardiovascular collapse possibly related to local anesthesia from chewing or sucking the softgel. CNS: sedation; headache; dizziness; mental confusion; visual hallucinations. GI: constipation; nausea; GI upset. Dermatologic: pruritus; skin eruptions. Other: nasal congestion; sensation of burning in the eyes; vague 'chilly' sensation; numbness of the chest; hypersensitivity. Rare instances of deliberate or accidental overdose have resulted in death. Read the Benzonatate (benzonatate softgels) Side Effects Center for a complete guide to possible side effectsLearn More »

Source: http://www.rxlist.com

Adults and children over 10 years of age: Usual dose is one 100 mg softgel t.i.d. as required. If necessary, up to 6 softgels daily may be given.

Source: http://www.rxlist.com

No information provided.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Benzonatate (benzonatate softgels) is indicated for the symptomatic relief of cough.

Source: http://www.rxlist.com

Hypersensitivity to benzonatate (benzonatate softgels) or related compounds.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Overdose may result in death. The drug is chemically related to tetracaine and other topical anesthetics and shares various aspects of their pharmacology and toxicology. Drugs of this type are generally well absorbed after ingestion. Signs and Symptoms If softgels are chewed or dissolved in the mouth, oropharyngeal anesthesia will develop rapidly. CNS stimulation may cause restlessness and tremors which may proceed to clonic convulsions followed by profound CNS depression. Treatment Evacuate gastric contents and administer copious amounts of activated charcoal slurry. Even in the conscious patient, cough and gag reflexes may be so depressed as to necessitate special attention to protection against aspiration of gastric contents and orally administered materials. Convulsions should be treated with a short-acting barbiturate given intravenously and carefully titrated for the smallest effective dosage. Intensive support of respiration and cardiovascular- renal function is an essential feature of the treatment of severe intoxication from overdose. Do not use CNS stimulants.

Source: http://www.rxlist.com

Each yellow softgel contains 100 mg of benzonatate (benzonatate softgels) and is available in bottles of 100's and 500's. The softgels should be protected from light, moisture and humidity, and stored at controlled room temperature 15°-30°C (59°-86°F). Dispense in a tight, light-resistant container as defined in USP/NF. Caution: Federal law prohibits dispensing without prescription.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Benzonatate (benzonatate softgels) is chemically related to anesthetic agents of the para-aminobenzoic acid class (e.g., procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication. Usage in Pregnancy Pregnancy Category C. Animal reproduction studies have not been conducted with benzonatate (benzonatate softgels) . It is also not known whether benzonatate (benzonatate softgels) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Benzonatate (benzonatate softgels) should be given to a pregnant woman only if clearly needed. Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk caution should be exercised when benzonatate (benzonatate softgels) is administered to a nursing woman. Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenicity, mutagenicity, and reproduction studies have not been conducted with benzonatate (benzonatate softgels) . Pediatric Use Safety and effectiveness in children below the age of 10 has not been established.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

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