Drug: Belladonna and Opium

Each belladonna and opium suppository contains (in a water-soluble base consisting of Polyethylene Glycol 400, 1450, 8000 and Polysorbate 60): Belladonna (16.2 mg) and Opium (30 mg): Powdered opium 30 mg (Warning: May be habit forming.) and powdered belladonna extract 16.2 mg. Belladonna (16.2 mg) and Opium (60 mg): Powdered opium 60 mg (Warning: May be habit forming.) and powdered belladonna extract 16.2 mg. This drug falls into the pharmacological/ therapeutic class of narcotic analgesic/ antispasmotic agents. The pharmacologically active principles present in the belladonna extract component of belladonna and opium suppositories are: Established Name: Atropine Chemical Name: dl Tropyl Tropate Chemical Structure:

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Belladonna may cause drowsiness, dry mouth, urinary retention, photophobia, rapid pulse, dizziness and blurred vision. Opium usage may result in constipation, nausea or vomiting. Pruritis and urticaria may occasionally occur. DRUG ABUSE AND DEPENDENCE Because of their content of opium, belladonna and opium suppositories are considered as Schedule II drugs by the Drug Enforcement Administration. No data exists on chronic abuse effects or dependence characteristics of belladonna and opium suppositories. Read the Belladonna and Opium (belladonna and opium) Side Effects Center for a complete guide to possible side effectsLearn More »

Source: http://www.rxlist.com

Adults One belladonna and opium suppository rectally once or twice daily, not to exceed four doses daily or as recommended by the physician. Moisten finger and suppository with water before inserting. Absorption is dependent on body hydration and not on body temperature. Not recommended for use in children 12 years of age and under.

Source: http://www.rxlist.com

Tell your doctor of all nonprescription or prescription medication you use, especially of: muscle relaxants, antidepressants (tricyclic), tranquilizers, sleep medicine, amantadine, antiparkinson drugs, narcotic pain relievers, cough medicines, quinidine, procainamide, disopyramide, MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), antihistamines, levodopa, digoxin, ketoconazole, potassium supplements, corticosteroids (e.g., prednisone), amphetamines, alcohol, cimetidine. Do not start or stop any medicine without doctor or pharmacist approval.Read the Belladonna and Opium Drug Interactions Center for a complete guide to possible interactions Learn More »

Source: http://www.rxlist.com

Belladonna and opium suppositories are used for relief of moderate to severe pain associated with ureteral spasm not responsive to non-narcotic analgesics and to space intervals between injections of opiates.

Source: http://www.rxlist.com

Do not use belladonna and opium suppositories in patients suffering from glaucoma, severe hepatic or renal disease, bronchial asthma, narcotic idiosyncrasies, respiratory depression, convulsive disorders, acute alcoholism, delirium tremens and premature labor.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

As with morphine and related narcotics, overdosage is characterized by respiratory depression, pinpoint pupils and coma. Respiratory depression may be reversed by intravenous administration of naloxone hydrochloride. In addition, supportive measures such as oxygenation, intravenous fluids and vasopressors should be used as indicated. As with atropine derivatives, hot, dry, flushed skin; dry mouth and hyperpyrexia may occur.

Source: http://www.rxlist.com

Belladonna (16.2 mg) and Opium (30 mg) suppositories are easy to open, color-coded and available in cartons of 12's.
    12's - NDC 0574-7045-12
Belladonna (16.2 mg) and Opium (60 mg) suppositories are easy to open, color coded and available in cartons of 12's and 20's. 12's - NDC 0574-7040-12 20's - NDC 0574-7040-20 Store at room temperature. DO NOT REFRIGERATE. Schedule II controlled substances - DEA order required. Caution: Federal law prohibits dispensing without prescription. Federal law prohibits transfer of this drug to any person other than the patient for whom it was prescribed. REFERENCE 1. Gilman, A.G. Goodman, L.S. & Gilman, A 6th Edition, The Pharmacological Basis of Therapeutics, MacMillan Pub. Co., NY 1980, pp. 121-127 2. Ibid, pp. 494-513Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Administer with caution to persons with a known idiosyncrasy to atropine or to atropine-like compounds; to persons known to be sensitive to or addicted to morphine or morphine-like drugs; to persons with cardiac disease, incipient glaucoma or prostatic hypertrophy. Caution should be used in the administration of this drug to elderly and debilitated patients and patients with increased intracranial pressure, toxic psychosis and myxedema. Pregnancy Category C Animal studies have not been conducted with belladonna and opium suppositories. It is also not known whether belladonna and opium suppositories can affect reproductive capacity. The active principles of belladonna and opium suppositories, atropine and morphine, are known to enter the fetal circulation. Regular use of opium alkaloids during pregnancy has resulted in addiction of the fetus leading to withdrawal symptoms in the neonate. Belladonna and opium suppositories therefore should be used by a pregnant woman with caution and only when clearly indicated. Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when belladonna and opium suppositories are administered to a nursing woman.Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

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